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KMID : 0613820050150020197
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Journal of Life Science
2005 Volume.15 No. 2 p.197 ~ p.201
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Effect of chiro-inositol from Soybean on Reducing Hyperglycemia and Its Role for Nutraceutic Supplement for Insulin Resistance
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Hong Yong-Geun
Park Yun-Bae
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Abstract
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Studies with diabetic mammalian systems showed that chiro-inositol administration decreased blood glucose levels. We investigated which foodstuffs contain large amounts of chiro-inositol by surveying vegetables, edible plants and other staples in an effort to explore the nutritional or therapeutic supplements of chiro-inositol for diabetic patients. In the course of our investigation, we found that soybean and soybean derivatives have high chiro-inositol levels (upto 20 ㎎/g). The purified chiroinositol from the soybean was then tested for reducing hyperglycemia by administrating the chiroinositol in streptozotocin-treated diabetic rats. The results showed that the intragastric administration of 50 ㎎ chiro-inositol/㎏ BW lowered hyperglycemia by 40% and that the effect was sustained for approximately 12 hr.
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